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US 4,308,388 AGranted
4-Azido-1-mercaptoacyl pipecolic acid
AssigneeE. R. Squibb & Sons, Inc.
InventorsEdward W. Petrillo, Jr., Frank L. Weisenborn
Life of this patent
Estimating the term…
Abstract
1-Mercaptoacyl proline or pipecolic acid having an azido group in the 4-position inhibits the conversion of angiotensin I to angiotensin II in mammals and is useful for the treatment of hypertension.
Claims6
A compound having the formula ##STR7## or a salt thereof, wherein R.sub.1 is hydrogen, alkyl, aryl, arylalkyl, alkanoyl, or arylcarbonyl;
- R.sub.2 is hydrogen, alkyl, alkylthio or trifluoromethyl;
- R.sub.3 is hydrogen, alkyl or arylalkyl;
- and
- n is 1 or 2;
- wherein the term "aryl" refers to phenyl or phenyl substituted with halogen, alkyl, alkoxy, alkylthio, hydroxy, alkanoyl, nitro, amino, dialkylamino, phenyl or trifluoromethyl groups;
- "alkyl" and "alkoxy" refer to groups having 1 to 8 carbon atoms;
- and "alkanoyl" refers to groups having up to 9 carbon atoms;
- and wherein the asymmetric center indicated by an asterisk (*) in the structural formula is in the D,L or L-configuration.
5 more elements
Dependencies are inferred from the claim text.