Method for purifying water-insoluble polyene antibiotics
AssigneeE. R. Squibb & Sons, Inc.
InventorWilliam W. Tang
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Abstract
A method for purifying water-insoluble polyene antibiotics, such as amphotericin and nystatin, is provided which method includes the step of passing a mixture of the polyene antibiotic dispersed in methanol through an ion exchange column whereby gram positive and gram negative bacteria are removed from the antibiotic.
Claims13
A method for purifying water-insoluble polyene antibiotics, which comprises forming a slurry of the antibiotic in an appropriate solvent, passing the antibiotic-solvent mixture through an ion exchange resin to filter gram positive bacteria and gram negative bacteria from the antibiotic and recovering purified antibiotic from the ion exchange resin.
Dependencies are inferred from the claim text.