2,4,5-Trisubstituted imidazolines and pharmaceutical compositions containing same
AssigneeCiba-Geigy Corporation
InventorsPier G. Ferrini, Richard Goschke
Life of this patent
Estimating the term…
Abstract
Compounds of the formula ##STR1## in which R.sub.1 and R.sub.2 independently of one another are substituted or unsubstituted aryl or hetero-aryl groups, R.sub.3 is hydrogen or lower alkyl and R.sub.4 is a substituted or unsubstituted aliphatic hydrocarbon radical, and their pharmaceutically usable salts. These compounds possess immunoregulatory, antithrombotic and antiinflammatory properties and can be used as active ingredients in medicaments. They are prepared, for example, by reacting compounds of the formulae ##STR2## in which one of the radicals X and Y is mercapto, which can be in the form of a salt, and the other is a radical replaceable by etherified mercapto, with one another.
Claims15
A compound of the formula ##STR12## in which R.sub.1 and R.sub.2 independently of one another are unsubstituted phenyl, or phenyl substituted by lower alkyl, lower alkoxy, halogen with an atomic number of not more than 35, nitro, amino, or N,N-di-lower alkylamino, unsubstituted pyridyl, or pyridyl substituted by lower alkyl or lower alkoxy, and unsubstituted thienyl, R.sub.3 is hydrogen or lower alkyl, and R.sub.4 is lower alkyl, phenyl-lower alkyl, phenyl-lower alkyl substituted in the phenyl-part by lower alkyl, lower alkoxy, halogen with an atomic number of not more than 35, nitro, amino, or N,N-di-lower alkylamino, or denotes hydroxy-lower alkyl, lower alkoxy-lower alkyl, lower alkyl-thio-lower alkyl, phenoxy-lower alkyl, or phenylthio-lower alkyl, wherein hydroxy, lower alkoxy, lower alkylthio, phenoxy and phenylthio are substituted in higher than the .alpha.-position, or a pharmaceutically usable salt thereof.
Dependencies are inferred from the claim text.