Penicillin derivatives
AssigneeBeecham Group Limited
InventorPeter H. Bentley
Life of this patent
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Abstract
A penicillin of formula (I) or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof: ##STR1## wherein R is C.sub.1-6 alkyl; an optionally substituted 5-membered heterocyclic ring containing one or two heteroatoms selected from oxygen, sulphur and nitrogen; phenyl; mono-substituted phenyl where the substituent is halogen, hydroxy, C.sub.1-6 alkoxy, nitro, amino, C.sub.1-6 alkyl, or C.sub.1-6 haloalkyl, C.sub.1-6 alkylcarbonyloxy, or C.sub.1-6 alkyl sulphonylamino; or di-substituted phenyl where the substituents are selected from hydroxy, halogen, methoxy, acetoxy and amino; and X represents a group of formula: ##STR2## wherein R.sup.1 represents C.sub.1 to C.sub.6 alkyl, or C.sub.1 to C.sub.6 alkoxy. Their preparation and use is described.
Claims13
A compound of formula (I) or a pharmaceutically acceptable salt or in vivo hydrolyzable ester thereof:
- ##STR19## wherein R is C.sub.1-6 alkyl;
- a substituted or unsubstituted 5-membered heterocyclic ring containing one or two heteroatoms selected from oxygen, sulphur and nitrogen;
- phenyl;
- mono-substituted phenyl where the substitutent is halogen, hydroxy, C.sub.1-6 alkoxy, nitro, amino, C.sub.1-6 alkyl, C.sub.1-6 haloalkyl, C.sub.1-6 alkylcarbonyloxy or C.sub.1-6 alkyl sulphonylamino;
- or di-substituted phenyl where the substituents are selected from hydroxy, halogen, methoxy, acetoxy and amino;
- and X represents a group of formula:
- ##STR20## wherein R.sup.1 represents C.sub.1 to C.sub.6 alkyl, or C.sub.1 to C.sub.6 alkoxy.
Dependencies are inferred from the claim text.