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US 4,308,181 AGranted
Polypeptide compositions
AssigneeAmerican Home Products Corporation
InventorWilliam H. McGregor
Life of this patent
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Abstract
There are disclosed tetrapeptides having the formula: R.sub.1 -Ser-His-Leu-R.sub.2 wherein R.sub.1 is N-lower alkanoyl or N-lower alkanoylGly; R.sub.2 is NH.sub.2 or Val-NH.sub.2 ; the fully protected peptide-resin intermediates thereof and pharmaceutically acceptable salts thereof. These tetrapeptides have the capability of inducing the proliferation of T-cell populations and thus are useful in a number of therapeutic areas.
Claims5
A tetrapeptide having the following formula:
- R.sub.1 -Ser-His-Leu-R.sub.2
- wherein R.sub.1 is N-lower alkanoyl or N-lower alkanoyGly;
- R.sub.2 is NH.sub.2 or Val-NH.sub.2 ;
- the fully protected peptide-resin intermediates thereof, and pharmaceutically acceptable salts thereof.
1 more element
A compound of the formula:
- ##STR2## wherein R.sub.1 is N-lower alkanoyl or N-lower alkanoylGly;
- R.sub.2 is NH.sub.2 or Val-NH.sub.2 ;
- A is a hydroxy protecting group;
- and B is an imidazole nitrogen protecting group.
1 more element
Dependencies are inferred from the claim text.