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US 4,307,245 AGranted
Amitriptyline conjugates to antigenic proteins and enzymes
AssigneeSyva Company
InventorsMae W. Hu, Prithipal Singh
Life of this patent
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Abstract
Amitriptyline functionalized compounds are provided for conjugation to antigenic compositions, particularly poly(amino acids), and enzymes. The antigenic conjugates are employed for the production of antibodies, which find particular use in immunoassays for the determination of amitriptyline, while the enzyme conjugate finds use in a homogeneous enzyme immunoassay for the determination of amitriptyline.
Claims6
Compound of the formula;
- Ami--X--RCO--Z
- wherein:
- Ami is of the formula:
- ##STR3## X is methylene or carbonyl;
- Z is hydrogen, hydroxyl, alkoxy of from 1 to 6 carbon atoms, N-oxy succinimide or p-nitrophenoxy ester;
- and
- R is an aliphatic hydrocarbon linking group of from one to seven carbon atoms having from zero to one site of unsaturation.
4 more elements
3-(.gamma.-carboxypropyl)amitriptyline.
2-(.gamma.-carboxypropyl)amitriptyline.
Dependencies are inferred from the claim text.