Ring expansion and chain extension process and reagents
AssigneeWisconsin Alumni Research Foundation
InventorsBarry M. Trost, John E. Vincent
Life of this patent
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Abstract
Expansion of a ring structure and extension of a noncyclic structure containing a ketosulfone grouping in the ring by reaction with a 2-X-alkyl-3-allyl-trialkylsilane intermediate in which X is a leaving group and conversion to an expanded ring.
Claims11
The compound having the general formula ##STR18## in which n is a number of from 1 to 3, R.sub.1, R.sub.2, R.sub.3 are carbons with or without alkyl substitution, R.sub.4 is a C.sub.1 -C.sub.18 aliphatic or cyclic group, with or without substituents, and X is a leaving group.
The compound 2-X-alkyl-3-allyl trialkyl silane in which X is a leaving group.
The method for extension of a ring compound having a keto-sulfone grouping(s) in the ring comprising reacting the keto-sulfone with a reagent compound in accordance with the reaction ##STR19## in which A and B are part of a ring structure or not part of a ring structure, X is a leaving group, R is a carbon group, with or without alkyl substitution, n is a number of from 1-3 and R.sub.2 is a substituted or unsubstituted C.sub.1 -C.sub.18 aliphatic or cyclic group.
The method for extension of a ring compound having a keto-sulfone grouping in the ring comprising reacting the keto-sulfone with a 2-X-alkyl-3-allyl-trialkyl silane in solvent solution in the presence of a base such as an alkali metal hydride in which X is a leaving group.
Dependencies are inferred from the claim text.