3-Vinyl-cephalosporins

A 3-vinyl-cephalosporin of the formula:

• ##STR153## in which n is 0 or 1, (a) the symbol R.sub.1 represents a hydrogen atom, a radical of the formula ##STR154## (which is in the syn or anti form, and in which R.sub.4 is a hydrogen atom or an amino protective radical and R.sub.5 is a hydrogen atom, an alkyl, vinyl or cyanomethyl radical or an oxime protective group),
• a benzhydryl radical or trityl radical,
• an acyl radical of the formula
• R.sub.6 CO--
• (in which R.sub.6 is a hydrogen atom or an alkyl radical which is unsubstituted or substituted by one or more halogen atoms or by a phenyl or phenoxy radical, or phenyl),
• a radical of the formula
• R.sub.7 OCO--
• in which R.sub.7 is a branched unsubstituted alkyl radical, a straight or branched alkyl radical carrying one or more substituents chosen from halogen atoms and cyano, trialkylsilyl, phenyl, and substituted phenyl (the substituents being one or more alkoxy, nitro or phenyl radicals), vinyl, allyl or quinolyl, or
• a nitrophenylthio radical, or
• R.sub.1 NH-- is replaced by a methyleneimino radical, in which the methylene radical is substituted by a dialkylamino group or phenyl group which is unsubstituted or substituted by one or more methoxy or nitro radicals, and the symbol R.sub.2 represents a hydrogen atom or an enzymatically easily removable radical of the formula ##STR155## (in which R.sub.8 represents an alkyl radical or the cyclohexyl radical and R.sub.9 represents a hydrogen atom or an alkyl radical) or a methoxymethyl, tert.-butyl, benzhydryl, p-nitrobenzyl or p-methoxybenzyl radical, or
• (b) the symbol R.sub.1 represents a hydrogen atom, an alkanoyl radical containing 1 to 8 carbon atoms, an alkanoyl radical containing 2 to 8 carbon atoms (substituted by chlorine or bromine atoms), azidoacetyl, cyanoacetyl, an acyl radical of the formula ##STR156## in which each Q is H or methyl and Ar represents a thien-2-yl, thien-3-yl, fur-2-yl, fur-3-yl, pyrrol-2-yl or pyrrol-3-yl radical or a phenyl radical which is unsubstituted or substituted by halogen atoms or by trifluoromethyl, hydroxyl, alkyl (containing 1 to 3 carbon atoms), alkoxyl (containing 1 to 3 carbon atoms), cyano or nitro radicals, of which at least one is situated in the meta- or in the para-position of the phenyl radical, an acyl radical of the formula
• Ar--X--CH.sub.2 --CO--
• in which X is oxygen or sulphur and Ar is defined as above or Ar--X-- represents pyrid-4-ylthio, an acyl radical of the formula ##STR157## in which Ar is as defined above and B represents an amino radical, an amino radical which is protected by a benzyloxycarbonyl, alkoxycarbonyl, cyclopentyloxycarbonyl, cyclohexyloxycarbonyl, benzhydryloxycarbonyl, trityl or 2,2,2-trichloro-ethoxycarbonyl group, a sulpho radical, a hydroxyl radical which is unprotected or protected by esterification with an alkanoic acid containing 1 to 6 carbon atoms, a carboxyl radical which is unprotected or protected by esterification with an alcohol of 1 to 6 carbon atoms, azido, cyano or carbamyl, or a 2-(sydnone-3)-alkanoyl radical (in which the alkanoyl part contains 1 to 3 carbon atoms), or a radical of the formula ##STR158## in which m is 0 to 2, or a 5-amino-adipyl radical in which the amino group is unprotected or protected by an alkanoyl radical containing 1 to 3 carbon atoms and unsubstituted or substituted by a chlorine atom, and in which the carboxyl group is protected by a benzhydryl,2,2,2-trichloroethyl,tert.-alkyl containing 4 to 6 carbon atoms, or nitrobenzyl group,
• or R.sub.1 NH is replaced by a cyclic imide group of a dicarboxylic acid and
• the symbol R.sub.2 represents a tert.-alkyl radical containing 4 to 6 carbon atoms, a tert.-alkenyl radical containing 6 or 7 carbon atoms, a tert.-alkynyl radical containing 6 or 7 carbon atoms, or a benzyl, methoxybenzyl, nitrobenzyl, 2,2,2-trichloroethyl, benzhydryl, succinimidomethyl or phthalimidomethyl radical or a hydrogen atom, and
• the symbol R.sub.3 represents a radical of the formula
• R'.sub.3 --SO.sub.2 O-- or or R".sub.3 --COO--
• in which R'.sub.3 represents an alkyl, trifluoromethyl or trichloromethyl radical or a phenyl radical which is unsubstituted or substituted by a halogen atom or by an alkyl or nitro radical, and R".sub.3 is defined like R'.sub.3 or represents an acylmethyl, 2-acylethyl, 2-acylpropyl, alkoxycarbonylmethyl, 2-alkoxycarbonylethyl or 2-alkoxycarbonylpropyl radical, the alkyl or acyl portions or radical which have been referred to above being (unless stated to the contrary) straight or branched and containing 1 to 4 carbon atoms, and the product being in the bicyclooct-2-ene or bicyclooct-3-ene form if n=0 and in the bicycloot-2-ene form if n=1, and the substituent in the 3-position being in the E- or Z-form, aas well as mixtures of their isomers, and the salts of the above compounds.