Aldose reductase inhibition by (Z)-5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene- 3-acetic acid
AssigneeAyerst McKenna and Harrison Ltd.
InventorsDushan M. Dvornik, Nicole Simard-Duquesne
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Abstract
Disclosed are new methods of using (Z)-5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3- acetic acid or a therapeutically acceptable salt thereof with an organic or inorganic base for the treatment of complications associated with diabetes mellitus. The compound inhibits lens aldose reductase in a diabetic mammal.
Claims3
A method of preventing or relieving a diabetic complication selected from at least one of cataracts, neuropathy, nephropathy and retinopathy in a diabetic mammal which comprises administering to said mammal an effective alleviating or prophylactic amount of (Z)-5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3- acetic acid, or a therapeutically acceptable salt thereof with an organic or inorganic base.
A method of preventing or relieving diabetes mellitus associated complications consisting of cataracts and retinopathy in a diabetic mammal which comprises topically administering to said mammal an effective alleviating or prophylactic amount of a sterile aqueous solution of (Z)-5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3- acetic acid, or a therapeutically acceptable salt thereof with an organic or inorganic base.
A method of preventing or relieving diabetes mellitus associated complications consisting of neuropathy and nephropathy in a diabetic mammal which comprises orally or parenterally administering to said mammal an effective alleviating or prophylactic amount of (Z)-5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3- acetic acid, or a therapeutically acceptable salt thereof with an organic or inorganic base.
Dependencies are inferred from the claim text.