Back to results
US 4,307,106 AGranted
Aminothiazoles
AssigneePfizer Inc.
InventorJoseph G. Lombardino
Life of this patent
Estimating the term…
Abstract
A series of 2-aralkylaminothiazoles and the pharmaceutically acceptable acid addition salts thereof having anti-inflammatory and immune regulant activity are disclosed. Preferred compounds include 2-phenethylamino-4-phenyl-thiazole, 2-(p-methoxyphenethylamino)-4-(p-fluorophenyl)-thiazole, 2-phenethylamino-4-phenyl-5-methyl-thiazole, 2-thenylamino-4-phenyl-thiazole and 2-thenylamino-4-(p-fluorophenyl)-thiazole.
Claims34
A compound of the formula ##STR7## and the pharmaceutically acceptable acid solution salts thereof, wherein R.sub.1 is selected from the group consisting of --(CH.sub.2).sub.2 --X, and --(CH.sub.2).sub.m Y, wherein
- X is selected from the group consisting of phenyl and monosubstituted phenyl, said substituent being selected from the group consisting of alkyl of 1 to 3 carbon atoms, hydroxy, alkoxy of 1 to 3 carbon atoms, chloro, bromo and fluoro;
- Y is selected from the group consisting of thienyl, monosubstituted thienyl, furyl and monosubstituted furyl, said substituent being selected from the group consisting of alkyl of 1 to 3 carbon atoms, chloro, bromo and fluoro;
- m is an integer from 1 to 2;
- R.sub.2 is selected from the group consisting of phenyl, thienyl, and monosubstituted phenyl, said substituent being selected from the group consisting of alkyl of 1 to 3 carbon atoms, chloro, bromo and fluoro;
- and R.sub.3 is selected from the group consisting of hydrogen and alkyl of 1 to 3 carbon atoms.
2 more elements
Dependencies are inferred from the claim text.