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US 4,307,103 AGranted
Dihydropyridine derivative, processes for preparation thereof and pharmaceutical composition comprising the same
AssigneeFujisawa Pharmaceutical Co., Ltd.
InventorsYoshinari Sato, Tsutomu Teraji
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Abstract
This invention relates to a dihydropyridine derivative and a salt thereof. More particularly, it relates to a new dihydropyridine derivative and a pharmaceutically acceptable salt thereof which have vasodilating and anti-hypertensive activities, to processes for the preparation thereof, and to pharmaceutical composition comprising the same for therapeutical treatment of cardiovascular disorder and hypertension in human being.
Claims13
A compound of the formula:
- ##STR17## wherein R.sup.1 is nitro, halogen, cyano, trihalo(lower)alkyl or phenyl,
- R.sup.2 is lower alkyl;
- [N-lower alkyl-N-mono or di halophenyl(lower)alkyl]amino(lower)alkyl;
- [N-lower alkyl-N-lower alkylphenyl(lower)alkyl]amino(lower)alkyl;
- [N-lower alkyl-N-lower alkoxyphenyl(lower)alkyl]amino(lower)alkyl;
- phthalimido(lower)alkyl;
- lower alkanoyloxy(lower)alkyl;
- lower alkylthio(lower)alkyl, phenyl(lower)alkylthio(lower)alkyl;
- or phenylthio(lower)alkyl;
- R.sup.3 and R.sup.4 are each lower alkyl, and
- R.sup.5 is cyano or 2-cyanovinyl with a proviso that
- when R.sup.1 is nitro, halogen, cyano or trihalo(lower)alkyl and R.sup.2 is lower alkyl, R.sup.3 and R.sup.4 is lower alkyl,
- then R.sup.5 is 2-cyanovinyl, and pharmaceutically acceptable salts thereof.
10 more elements
Dependencies are inferred from the claim text.