Branched chain and cycloaliphatic esters of the androstane and oestrane series and pharmaceutical compositions containing same
AssigneeAkzona Incorporated
InventorLambert J. W. M. Tax
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AssigneeAkzona Incorporated
InventorLambert J. W. M. Tax
Estimating the term…
There are disclosed branched chain and cycloaliphatic esters of steroids having the formula: ##STR1## where R is H or CH.sub.3 ; R.sub.1 is H or CH.sub.3 ; R.sub.2 is H or CH.sub.3 ; R.sub.3 is H, OH, CH.sub.3 or Cl; R.sub.4 is H or C.sub.1 to C.sub.4 alkyl; R.sub.5 is H, C.sub.1 to C.sub.4 alkyl or CF.sub.3 ; R.sub.6 is H, C.sub.1 to C.sub.4 alkyl, C.sub.1 to C.sub.4 alkoxy, halogen or .beta.-OH providing that when R.sub.6 is .beta.-OH, the steroid also contains 9.alpha.-F and further providing that R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and R.sub.6 represent at least 4 and at most 5 hydrogen atoms, except in the case of a .DELTA..sup.1,4 -steroid, in which case R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are all hydrogen; R.sub.7 is H or CH.sub.3 ; R.sub.8 is ##STR2## providing the R.sub.8 is --OH or ##STR3## when the steroid has an aromatic ring A.
A compound of the formula ##STR11## of the 5.alpha.H analog thereof, wherein
Dependencies are inferred from the claim text.