Antibiotic AR-5 complex, antibiotics coproduced therewith and derivatives thereof
AssigneeSchering Corporation
InventorsJ. Allan Waitz, Walter Reiblein, Imbi Truumees
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Abstract
The Antibiotic AR-5 complex is elaborated by a novel species of the Micromonospora; namely, Micromonospora polytrota. The microorganism also elaborates a number of minor components including the gentamicin complex and a complex of gentamicin antibiotics.
Claims21
An antibacterial compound selected from the group consisting of antibiotics AR-5 component 1;
- AR-5 component 2;
- 12,13-desepoxy AR-5 component 1;
- 12,13-desepoxy AR-5 component 2 having the following planar structural formulae:
- ##STR2## the non-toxic pharmaceutically acceptable carboxylic acid esters thereof and the non-toxic pharmaceutically acceptable acid addition salts of said compounds wherein each of said esters is derived from a mono-carboxylic acid, or is a hemi-ester of a dicarboxylic acid each having 2 to 18 carbon atoms;
- wherein in formula 1, R is hydrogen in Antibiotic AR-5 component 1 and is hydroxyl in Antibiotic AR-5 component 2 and wherein in formula 2, R is hydrogen in 12,13-desepoxy AR-5 component 1 and is hydroxyl in 12,13-desepoxy AR-5 component 2.
An Antibacterially active mixture of Antibiotic AR-5 Component 1 and Antibiotic AR-5 Component 2 wherein Antibiotic AR-5 Component 1 constitutes about 40 to 60% of the mixture, Antibiotic AR-5 Component 2 constituting the remainder of the mixture, said mixture being free of other coproduced antibiotics.
Dependencies are inferred from the claim text.