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US 4,307,072 AGranted
N-Triiodobenzoylaminoacyl polyhydroxic amines
AssigneeMallinckrodt Inc.
InventorKenneth R. Smith
Life of this patent
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Abstract
Nonionic triiodobenzoyl amino acyl derivatives of polyhydroxy amines. Such amines are useful as nonionic X-ray contrast agents. For Example 2-(3-acetamido-2,4,6-triiodo-5-N-methylacetamidobenzoyl glycylamino)-2-deoxy-D-glucitol is especially useful in angiography.
Claims37
A compound of the formula ##STR36## wherein X and Y are each nonionic functions compatible with low toxicity and/or water solubility in the 2,4,6-triiodo configuration,
- A is an amino substituted lower alkanoic acid coupler and ##STR37## is a monovalent residue of a polyhydroxy amine, wherein N is a nitrogen atom,
- R is hydrogen, lower alkyl, hydroxy-lower alkyl or polyhydroxy lower alkyl, Z is polyhydroxy lower alkyl or oxo polyhydroxy lower alkyl.
Dependencies are inferred from the claim text.