Inert organic solvent dispersion of alkali hydroxide and reaction using the same
AssigneeIhara Chemical Industry Co., Ltd.
InventorsYoshiki Nakayama, Taro Izawa, Yasushi Higuchi, Yutaka Ohishi, Chihiro Yazawa
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Abstract
An inert organic solvent dispersion of alkali hydroxide is prepared by mixing an alkali hydroxide, an inert organic solvent and a stabilizer and heating and stirring at the temperature for forming the pasty alkali hydroxide and cooling the dispersion. The dispersion of alkali hydroxide is used in a reaction of an active methylene compound with an organoalkyl halide such as a reaction of a halophenylacetonitrile with an isopropyl halide to obtain .alpha.-isopropyl halophenylacetonitrile.
Claims8
In a reaction of an active methylene compound selected from the group consisting of malonic nitrile, malonic acid, diethyl malonate, cyanoacetic acid, methyl cyanoacetate, acetylacetic acid, methyl acetylacetate, acetylacetone, phenylacetonitrile, 4-ethylphenylacetonitrile, 3,4-dimethylphenylacetonitrile, 3-trifluoromethylphenylacetonitrile, phenylacetic acid, 4-chlorophenyl acetic acid, 2-bromophenyl acetic acid, 4-ethyl phenyl acetic acid, phenylthioacetonitrile, .alpha.-methylphenylacetonitrile, .alpha.-methoxyphenylacetonitrile, .beta.-cyanophenylpropionitrile, diphenylacetonitrile, propionaldehyde, cyclohexanone and 2-methylcyclohexanone with an organoalkyl compound selected from the group consisting of alkyl halides, aralkyl halides, vinyl halides, alkyl vinyl halides, haloacetonitriles and haloacetates to produce a methylene organolkylated compound, the improvement characterized in that the reaction is carried out in an inert organic solvent dispersion of fine alkali hydroxide obtained by mixing an alkali hydroxide and an inert organic solvent, treating the mixture to form a dispersion of fine particles of the alkali hydroxide having a diameter of 100 m.mu. to 500.mu..
In a reaction of a halophenylacetonitrile with an isopropyl halide to produce .alpha.-isopropyl halophenylacetonitrile, the improvement characterized in that the reaction is carried out in an inert organic solvent dispersion of fine alkali hydroxide obtained by mixing an alkali hydroxide and an inert organic solvent, heating the mixture to form a paste and stirring the mixture to form a dispersion of fine particles of the alkali hydroxide, and cooling the mixture in the dispersed form while continuing stirring to yield alkali hydroxide particles having a diameter of 100 m.mu. to 500.mu..
Dependencies are inferred from the claim text.