1.alpha., 25-dihydroxy-2.beta.-fluorovitamin D.sub.3
AssigneeWisconsin Alumni Research Foundation
InventorsHector F. DeLuca, Heinrich K. Schnoes, Nobuo Ikekawa, Yoko Tanaka, Masuo Morisaki, Jun-ichi Oshida
Life of this patent
Estimating the term…
Abstract
The invention provides new derivatives of vitamin D.sub.3, specifically, 1.alpha.,25-dihydroxy-2.beta.-fluorocholecalciferol. The compound is characterized by vitamin D-like activity as measured by its ability to stimulate intestinal calcium transport, mobilization of calcium from bone, increase serum inorganic phosphorous and in their antirachitic activity. The compound, could, therefore, find ready application as a substitute for vitamin D in its various known applications and in the treatment of various metabolic bone diseases.
Claims3
Compounds having the formula:
- ##STR2## where each of R, R.sub.1 and R.sub.2 is selected from the group consisting of hydrogen and an acyl group having from 1 to about 6 carbon atoms.
1.alpha.,25-dihydroxy-2.beta.-fluorovitamin D.sub.3.
Dependencies are inferred from the claim text.