Isolation storage and intermixing syringe for medicants

An isolation storage and intermixing syringe for medicants for use when and where positive isolation and sterility of two components are to be maintained until the time of intermixing and use, said intermixing syringe including:

• (a) an outer housing of a rigid composition, said housing having an intermediate portion with a relatively constant diameter and with a substantially closed front end with an expelling aperture therethrough, the rear end of this housing having an opening substantially the size of the inner diameter provided in the intermediate portion of the housing;
• (b) a rigid insert provided in the forward end of the housing and adapted to be a snug fit in said forward end, said insert having a recess and a plurality of through conduits from an inner face to the recess;
• (c) a flapper valve member providing a one-way valve means and mounted in said recess to inhibit flow into the housing while permitting flow from said housing to and through the conduits;
• (d) a filter disposed in said recess and disposed to filter fluid flow from the housing interior to and through the expelling aperture;
• (e) a rigid cone-like projection provided on the insert and disposed so as to extend into the intermediate housing portion;
• (f) a glass ampule freely slidable in the housing and adapted to retain the medicant portion in a sterile and unaffected condition until broken for intermixing;
• (g) a rigid tubular member slidably carried in the housing and adapted to retain a determined quantity of diluent, this tubular member having a closed rear end and an open front end of a size substantially at the maximum diameter of configuration;
• (h) a plunger end mountable in the open end of the tubular member and including at least one outwardly extending rib to provide a sliding seal of the plunger end in the interior diameter of the intermediate portion of the housing, this plunger end also having a through longitudinal passageway and an incomplete longitudinal passageway extending from the inner end of the mounted plunger end to an outwardly directed conduit connecting to an air pathway to the outer portion of the housing, this plunger end made of a resilient material;
• (i) a one-way valve means closing the through passageway in the plunger end to flow of fluid from the housing to the tubular member through the plunger end while said valve is open to flow from the tubular member to the housing;
• (j) a one-way valve means closing the incomplete passageway in the plunger end to a flow of stored diluent in the tubular member and with the forward movement of the plunger end on the tubular member the glass ampule is caused to fracture and expose its contents, and the outward movement of the tubular member causes a reduced pressure to be provided in the housing and under this influence of reduced pressure the diluent is transferred from the tubular member to the housing while the air flows into said tubular member during transfer, the transfer and shaking inducing the desired intermix, after which the plunger end is moved forwardly toward the insert to cause the intermixed fluid medicant to be expelled through the insert, the filter and from the housing.