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AssigneeRegents of the University of Minnesota
InventorsFrank D. Dorman, Thomas D. Rohde, Thomas G. Rublein
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A method of preventing the precipitation of hormone preparations within drug delivery systems that depend on the fluidity of the infusate for proper function. A non-toxic water soluble detergent is dissolved in the hormone solution prior to the introduction of the solution into the drug delivery system. The detergent is added in amount sufficient to prevent precipitation of the hormone during long-term storage in the drug delivery device. According to one form of usage, the hormone-detergent solution is charged to the pressurized drug storage chamber of an implanted infusion pump by injection through the patient's skin. As the solution is discharged from the delivery device by the constant pressure exerted upon the storage chamber, its low rate of flow is controlled by a restricted fluid passage. The solution is conveyed to an infusion site and diluted by the blood stream.
A method of maintaining the fluidity of hormone solutions for parenteral administration at a low flow rate to a chronically ill patient suffering from a hormone-deficiency disease from a drug delivery device that depends on the fluidity of the infusate for proper functioning, without loss of biological activity, which method comprises:
A method of aldministering a hormone solution at a low flow rate to a chronically ill patient suffering from a hormone-deficiency disease, which method comprises:
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