3-[2-Hydroxy-4-(substituted)phenyl]-cycloalkanol analgesic agents
AssigneePfizer Inc.
InventorsCharles A. Harbert, Michael R. Johnson, Lawrence S. Melvin, Jr.
Life of this patent
Estimating the term…
Abstract
Cycloalkanones, cycloalkanols and unsaturated analogs thereof, each of which has at the 3-position a 2-hydroxy-4-substituted phenyl group wherein the 4-position substituent is alkyl which can have an oxygen atom as part of the chain, or aralkyl which can have an oxygen atom as part of the alkyl chain, their use for pharmacological and medicinal purposes, intermediates therefor and processes for their preparation.
Claims12
A compound selected from the group consisting of those having the formula ##STR42## wherein R is selected from the group consisting of saturated and unsaturated cycloalkyl moieties selected from the group consisting of ##STR43## wherein A is hydrogen;
- B is hydroxy;
- R.sub.1 is selected from the group consisting of hydrogen and benzyl;
- R.sub.2 is selected from the group consisting of hydrogen, alkyl having from one to six carbon atoms and alkenyl having from three to six carbon atoms;
- R.sub.3 is hydrogen;
- R.sub.4 is selected from the group consisting of hydrogen and alkyl having from one to six carbon atoms;
- Z is selected from the group consisting of
- (a) alkylene having from seven to eleven carbon atoms;
- and
- (b) (alk.sub.1).sub.m --O--(alk.sub.2).sub.n -- wherein each of (alk.sub.1) and (alk.sub.2) is alkylene having from one to eleven carbon atoms;
- each of m and n is 0 or 1;
- with the provisos that the summation of carbon atoms in (alk.sub.1) plus (alk.sub.2) is not less than seven or greater than eleven;
- and at least one of m and n is 1 and
- W is hydrogen.
Dependencies are inferred from the claim text.