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US 4,306,095 AGranted
Prostane derivatives
AssigneeImperial Chemical Industries PLC
InventorJean Bowler
Life of this patent
Estimating the term…
Abstract
The disclosure relates to novel 4-cis-prostenoic acid derivatives, for example 16-(3-chlorophenoxy)-9.alpha.,11.alpha.,15-trihydroxy-17,18,19,20-tetranor -4-cis, 13-trans-prostadienoic acid, to chemical processes for their manufacture, to pharmaceutical and veterinary compositions containing them, and to the use of the compounds in a method of luteolysis, a method of inhibiting blood platelet aggregation, and a method of inhibiting gastric acid production.
Claims9
A prostane derivative of the formula:
- ##STR30## R.sup.1 is hydroxymethyl, R.sup.2, R.sup.3 and R.sup.4, which may be the same or different, are each hydrogen or C.sub.1-5 alkyl, X is ethylene or trans-vinylene, Y is C.sub.1-5 alkyleneoxy, wherein the oxygen is bonded to R.sup.5, C.sub.1-5 alkylene or a direct bond, R.sup.5 is phenyl or naphthyl which is unsubstituted or is substituted by one or more substituents selected from halogen, nitro, and C.sub.1-5 alkyl, alkoxy and halogenoalkyl, and n is 1 to 4.
Dependencies are inferred from the claim text.