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US 4,306,067 AGranted
Precursors of phenyl-quinolizidines
AssigneeHoffmann-La Roche Inc.
InventorsRene' Imhof, Emilio Kyburz
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Abstract
Phenyl-quinolizidines of the formula ##STR1## wherein X, Y, R.sup.1 and R.sup.2 are as hereinafter set forth, are described. The compounds of formula I are useful as antipsychotics, antiemetics and analgesics.
Claims5
A compound of the formula ##STR29## wherein X is hydrogen, fluorine, chlorine, lower alkoxy, lower alky or trifluoromethyl;
- Y is hydrogen, fluorine, chlorine, lower alkoxy or lower alkyl;
- and A"' is a group of the formula ##STR30## wherein R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are as follows:
- R.sup.3 is oxygen or sulfur;
- R.sup.4 is hydrogen or lower alkyl;
- R.sup.5 and R.sup.6, independently, are hydrogen, methyl, fluorine, chlorine, methoxy or trifluoromethyl, or taken together, are --(CH.sub.2).sub.4 --, provided that R.sup.3 is oxygen when R.sup.4 is lower alkyl, its racemate or an enantiomer thereof.
2 more elements
Dependencies are inferred from the claim text.