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US 4,306,065 AGranted
2-Aryl-4-substituted quinazolines
AssigneeA. H. Robins Company, Incorporated
InventorYing-Ho Chen
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Abstract
Novel hypotensive agents are disclosed which are quinazolines substituted in the 2 and 4 position having the general formula: ##STR1## wherein Q is a secondary amine radical illustrated by loweralkanolylamino or a tertiary amine radical such as pyrrolidinyl, piperidinyl or piperazinyl, any of which may be substituted by various groups such as loweralkanolyl.
Claims24
A compound suitable for treating hypertension in warm blooded animals selected from the group having the formula:
- ##STR7## wherein Q is ##STR8## R is selected from hydrogen, hydroxy, loweralkoxy, loweralkanolyl, phenoxy or phenoxy substituted by loweralkyl, loweralkoxy, trifluoromethyl, amino, nitro or halo;
- Z is selected from ##STR9## and p is zero to one inclusive;
- R.sub.1 is selected from loweralkyl, 2-pyridyl, loweralkenyloxy-loweralkanolyl, loweralkynyloxy-loweralkanolyl, loweralkanyloxy-lowralkanolyl, phenoxy-loweralkanolyl and phenoxy-loweralkanolyl having phenoxy substituted by loweralkoxy, loweralkyl, nitro, amino, trifluoromethyl and halo;
- R.sub.2 is selected from hydrogen, hydroxy and loweralkyl, loweralkoxy, phenoxy or naphthoxy;
- R.sub.3 is selected from 4-cyanocycloalkyl-loweralkyl, phenoxy-loweralkanolyl and phenoxy-loweralkanolyl having phenoxy substituted by loweralkoxy, loweralkyl, nitro, amino, trifluoromethyl and halo;
- R.sub.4 is selected from hydrogen or loweralkyl,
- X is selected from hydrogen, loweralkyl, loweralkoxy, nitro, amino or halo and n is one to three;
- Y is loweralkyl and m is 0 to 2 inclusive and the pharmaceutically acceptable addition salts and hydrates thereof.
5 more elements
Dependencies are inferred from the claim text.