Process for cultivation of hemolytic Streptococcus pyogenes
AssigneeKanebo, Ltd.
InventorsShintaro Inoue, Mikio Sotomura, Hiroshi Tanaka, Seiichi Iwamoto, Norimasa Takamatsu, Akira Suzuki, Isamu Utsumi
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Abstract
A process for cultivation of Streptococcus pyogenes comprising cultivating Streptococcus pyogenes in a culture medium for multiplication of bacterial cells having an anti-tumor activity, characterized by (A) using the culture medium containing fermentable carbon sources and (B) maintaining pH of the culture medium at 5.6 or more during the course of cultivation.
Claims9
In a process for the cultivation of Streptococcus pyogenes which comprises cultivating Streptococcus pyogenes in a culture medium for multiplication of bacterial cells having an anti-tumor activity, the improvement wherein
- (A) the culture medium used contains fermentable carbon sources in an amount of 0.3 to 5% of the culture medium and
- (B) the pH of the culture medium is maintained in the range of 6 to 7.5 during the course of cultivation.
Dependencies are inferred from the claim text.