Hypolipidemic and antiatherosclerotic 4-(polyfluoro-alkylamino)phenyl compounds
AssigneeAmerican Cyanamid Company
InventorRobert G. Shepherd
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Abstract
This disclosure describes novel 4-(polyfluoroalkylamino)phenyl compounds useful as hypolipidemic and antiatherosclerotic agents.
Claims22
A compound of the formula ##STR3## wherein R.sub.1 is a saturated or unsaturated hydrocarbon radical of 7-19 carbon atoms which may be branched or unbranched and which may contain a saturated or unsaturated cycloalkyl group, said radical containing one or more perfluorinated (-CF.sub.2 - or -CF.sub.3) carbon atoms excluding the carbon adjacent to the nitrogen atom;
- R.sub.2 is hydrogen or methyl;
- and
- J is ##STR4## Z being hydrogen.
A compound of the formula ##STR5## wherein R.sub.1 is a saturated loweralkyl group containing one or more perfluorinated (-CF.sub.2 - or -CF.sub.3) carbon atoms excluding the carbon adjacent to the nitrogen atom;
- Y is a saturated alkylene group containing 6-18 carbon atoms which may be branched or unbranched;
- and Z is hydrogen.
The compound 4-[15-(trifluoromethyl)pentadecylamino]benzaldehyde.
The compound 4-[6-(Trifluoromethyl)hexylamino]benzaldehyde.
The compound 4-[11-(Trifluoromethyl)undecylamino]benzaldehyde.
The compound 4-[17-(Trifluoromethyl)heptadecylamino]benzaldehyde.
The compound 4-[7-(Trifluoromethyl)undecylamino]benzaldehyde.
The compound 4-[11-(Pentafluoroethyl)undecylamino]benzaldehyde.
The compound 4-[16-(Pentafluoroethyl)hexadecylamino]benzaldehyde.
The compound 4-[5-(Pentadecafluoroheptyl)pentylamino]benzaldehyde.
The compound 4-(6,6-Difluorohexadecylamino)benzaldehyde.
The compound 4-(14,14-Difluoropentadecylamino)benzaldehyde.
The compound 4-[(Pentadecafluoroheptyl)methylamino]benzaldehyde.
A compound 4-[(Hentricontafluoropentadecyl)methylamino]benzaldehyde.
The compound 4-[15-(Trifluoromethyl)-12-pentadecnylamino]benzaldehyde.
Dependencies are inferred from the claim text.