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US 4,305,949 AGranted
Amide therapeutic agents
AssigneePfizer Inc.
InventorsCharles A. Harbert, Joseph G. Lombardino
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AssigneePfizer Inc.
InventorsCharles A. Harbert, Joseph G. Lombardino
Estimating the term…
A series of N-(2-thiazolyl)amides has been prepared, including their pharmaceutically acceptable acid addition salts as well as pharmaceutical compositions containing same. These compounds are useful in therapy as anti-inflammatory agents in addition to being useful as immunoregulatory agents for modulating various body immune responses. Preferred member compounds include N-(2-thiazolyl)-.alpha.-methylaminoacetamide, N-(2-thiazolyl)-.alpha.-benzylaminoacetamide, N-(2-thiazolyl)-.alpha.-(p-fluorobenzylamino)acetamide, N-(2-thiazolyl)-.alpha.-(2-thenylamino)acetamide and N-(4-methyl-2-thiazolyl)-.alpha.-amino-.beta.-phenylpropionamide, and their hydrohalide acid addition salts. Three different methods of preparation are provided and these are all described in some detail, including the various synthetic routes leading to the required novel intermediates and/or starting materials.
A compound selected from the group consisting of N-(2-thiazolyl)amides of the formula:
A pharmaceutical composition suitable for alleviating inflammatory conditions and regulating body immune responses comprising a pharmaceutically acceptable carrier and a therapeutically-effective amount of a compound selected from the group consisting of N-(2-thiazoyl)amides of the formula:
Dependencies are inferred from the claim text.