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US 4,305,945 AGranted
Isoureas and isothioureas
AssigneeSmith Kline & French Laboratories Limited
InventorsCharon R. Ganellin, Robert J. Ife, David A. A. Owen
Life of this patent
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Abstract
The compounds are isoureas and isothioureas which have an O- or S- alkylpyrimidone substituent and which are histamine H.sub.2 -antagonists and antiinflammatory agents. A specific compound of this invention is 2-[5-(O-isoureido)pentylamino]-5-(6-methyl-3-pyridylmethyl)-4-pyrimidone.
Claims18
A compound of the formula ##STR10## in which R.sup.1 and R.sup.2 are hydrogen or lower alkyl;
- Y is sulphur or oxygen;
- n is from 3 to 8;
- X is oxygen or sulphur;
- Z is hydrogen or lower alkyl;
- A is straight or branched C.sub.1 -C.sub.5 alkylene or --(CH.sub.2).sub.p W(CH.sub.2).sub.q --where W is oxygen or sulphur and the sum of p and q is 1 to 4;
- and B is a heteroaryl group selected from pyridyl, N-oxopyridyl, pyrimidyl, pyrazyl, pyridazyl, quinolyl, isoquinolyl, 5,6,7,8-tetrahydroquinolyl and 1,3-dioxolopyridyl optionally substituted by one or two lower alkyl, lower alkoxy, halo, hydroxy or amino groups, in the form of the free base or a pharmaceutically acceptable acid addition salt thereof.
3 more elements
Dependencies are inferred from the claim text.