2,8-Disubstituted-10-hydroxy-5,5-dimethyl-tetrahydro-and hexahydro-5H-[1]-benzopyrano[4,3-c]pyridines, compositions and use
AssigneeAbbott Laboratories
InventorHarold E. Zaugg
Life of this patent
Estimating the term…
Abstract
The present invention provides 2,8-disubstituted-10-hydroxy-5,5-dimethyl-tetrahydro-and hexahydro-5H-[1]-benzopyrano[4,3-c]pyridines represented by Formulae I-III: ##STR1## wherein: R is selected from the group consisting of C.sub.4 -C.sub.20 straight or branched chain alkyl, C.sub.8 14 C.sub.20 straight or branched chain arylalkyl; n is an integer from 1-4 inclusive; and X is OH, NR.sub.1 R.sub.2, R.sub.1 and R.sub.2 being the same or different members of the group consisting of hydrogen and loweralkyl, and ##STR2## wherein Y is CH.sub.2, S, O or NR.sub.1 ; and the pharmaceutically acceptable salts thereof. The compounds are useful as antihypertensive agents.
Claims34
A 2,8-disubstituted benzopyranopyridine represented by the formulae:
- ##STR13## wherein:
- R is selected from the group consisting of C.sub.4 -C.sub.20 straight or branched chain alkyl, C.sub.8 -C.sub.20 straight or branched chain arylalkyl;
- n is an integer from 1-4 inclusive;
- and X is OH, NR.sub.1 R.sub.2, R.sub.1 and R.sub.2 being the same or different members of the group consisting of hydrogen and loweralkyl, and ##STR14## wherein Y is CH.sub.2, S, O or NR.sub.1;
- and the pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.