Method for preparing O-4-(hydroxyalkyl)-thiophenyl phosphates
AssigneeCommonwealth Scientific and Industrial Research Organization
InventorFrancis W. Jones
Life of this patent
Estimating the term…
Abstract
Organophosphorus esters, useful as intermediates in the synthesis of fibre-reactive insect proofing agents for keratinous materials, are prepared as follows: ##STR1## wherein: R.sub.1 is an alkyl, alkoxy, alkylamino or alkylmercapto radical with 1-6 carbon atoms a dialkylamino radical of 2 to 6 carbon atoms or a phenyl or amino radical; R.sub.2 is an alkyl radical of 1-6 carbon atoms; R.sub.3 is a divalent alkylene radical of 1-12 carbon atoms; X is either a sulphur or oxygen atom; and hal is either a chlorine or bromine atom.
Claims20
A method for the preparation of 0-4-(hydroxyalkyl)-thiophenyl) organophosphorus esters of the formula (I):
- wherein:
- the phenolic hydroxyl group of a compound of the formula (VIII):
- ##STR16## is phosphorylated by reaction with a compound of the formula:
- ##STR17## in the presence of an acid acceptor to form a compound of the formula:
- ##STR18## and the formyl ester group is removed from the compound of formula (X) by reaction in an alkaline solution where R.sub.1 is an alkyl, alkoxy, alkylamino or alkylmercapto radical with 1-6 carbon atoms a dialkylamino radical of 2 to 6 carbon atoms or a phenyl or amino radical:
- R.sub.2 is an alkyl radical of 1-6 carbon atoms;
- R.sub.3 is a divalent alkylene radical of 1-12 carbon atoms;
- X is either a sulphur or oxygen atom;
- and
- hal is either a chlorine or bromine atom.
A method according to any of the preceding claims in which the phosphorylation of compound (VIII) is carried out in the presence of an inert solvent or dilutent at a temperature of between 20.degree. and 150.degree. C.
Dependencies are inferred from the claim text.