Polypeptide compositions
AssigneeAmerican Home Products Corporation
InventorVictor M. Garsky
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Abstract
There are disclosed polypeptides having the formula: R-Arg-Lys-Asp-Val-D-Ala-R.sub.1 wherein R is hydrogen, alkanoyl of 1-4 carbon atoms or aroyl of 6-10 carbon atoms; and R.sub.1 is amino, monoalkylamino of 1-4 carbon atoms, dialkylamino of 1-4 carbon atoms, hydroxy, alkoxy of 1-4 carbon atoms, ##STR1## the fully protected peptide-resin intermediates thereof, or pharmaceutically acceptable salts thereof. These polypeptides have the capability of inducing the differentiation of t-lymphocytes and thus are useful in a number of therapeutic areas.
Claims4
A polypeptide having the following formula:
- R-Arg-Lys-Asp-Val-D-Ala-R.sub.1
- wherein
- R is hydrogen, alkanoyl of 1-4 carbon atoms or aroyl of 6-10 carbon atoms;
- and
- R.sub.1 is amino, monoalkylamino of 1-4 carbon atoms, dialkylamino of 1-4 carbon atoms, hydroxy, alkoxy of 1-4 carbon atoms, ##STR4## the fully protected peptide-resin intermediates thereof, or pharmaceutically acceptable salts thereof.
A compound of the formula:
- ##STR5## wherein A is an .alpha.-amino protecting group;
- B is a protecting group for the guanyl group of arginine;
- C is an amino protecting group;
- and
- D is a protecting group for the side chain carboxy group of aspartic acid.
The compound of claim 5 wherein:
- A is t-butyloxycarbonyl;
- B is tosyl;
- C is 2-chlorobenzyloxycarbonyl;
- and
- D is benzyl.
Dependencies are inferred from the claim text.