Method and apparatus for high resolution nuclear magnetic resonance spectroscopy
AssigneeGesellschaft fur Biotechnologische Forschung mbH
InventorsLudger Ernst, David N. Lincoln, Viktor Wray
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Abstract
A nuclear magnetic resonance line broadened by an inhomogeneous magnetic field can be narrowed by rotating the sample. This, however, produces rotational side bands having a frequency equal to the frequency of a main signal plus/minus integer multiples of the speed of rotation. The generation of such spurious rotational side bands is avoided by varying the speed of rotation of the sample within a predetermined range of speeds. The lower limit of said range should be high enough to provide for narrowing the nuclear magnetic resonance lines by rotating the sample.
Claims12
A method of suppressing rotational side bands in a spectrum of high resolution nuclear magnetic resonance, wherein a rotating sample is subjected to a not entirely homogeneous magnetic field, and a high frequency field, and the nuclear magnetic resonance of the sample is determined as a function of the frequency of the high frequency field or the field strength of the magnetic field, characterized in that the rotational speed of the rotating sample is varied continuously in a range which is above a predetermined minimum speed while the nuclear magnetic resonance spectrum of the sample is being determined.
A nuclear magnetic resonance spectrometer comprising
- means for supporting a sample at a predetermined location;
- means for producing a magnetic field at said location, said magnetic field being essentially, but not completely homogeneous;
- means for producing a high frequency field at said location;
- means for varying at least one of said fields for exciting nuclear magmetic resonances;
- means for sensing the high frequency absorption of said sample;
- means for spinning said sample with a speed of rotation;
- the improvement consisting in
- means for varying said speed of rotation of said sample within a range of speeds while the high frequency absorption of said sample is being sensed.
A method of suppressing rotational side bands in a spectrum of high resolution nuclear magnetic resonance, wherein a rotating sample is subjected to a not entirely homogeneous magnetic field, and a high frequency field, and the nuclear magnetic resonance of the sample is determined as a function of the frequency of the high frequency field or the field strength of the magnetic field, characterized in that the rotational speed of the rotating sample is varied in steps in a range which is above a predetermined minimum speed while the nuclear magnetic resonance spectrum of the sample is being determined.
Dependencies are inferred from the claim text.