Process for the preparation of 2-(3-phenoxy-phenyl)-propionic acid
AssigneeChinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt.
InventorsEndre Palosi, Gergely Heja, Dezso Korbonits, Pal Kiss, Csaba Gonczi, Judit Cser nee Kun, Ida Szvoboda nee Kanzel, Gabor Szabo, Tamas Kallay, Laszlo Ledniczky, Maria Szomor nee Wundele
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Abstract
2-(3-Phenoxy-phenyl)-propionic acid or its pharmaceutical treatments, are prepared by hydrolyzing and partially decarboxylating ##STR1## wherein R=C.sub.1 -C.sub.6 alkyl or amino, the latter compounds being themselves new and, where R=C.sub.1 -C.sub.6 alkyl, have antiinflammatory pharmaceutical properties.
Claims6
A process for the preparation of 2-(3-phenoxy-phenyl-propionic acid or a pharmaceutically effective salt thereof which comprises hydrolyzing and partially decarboxylating 2-cyano-2-(3-phenoxy-phenyl)-propionic acid amide in water or in an aqueous organic solvent mixture in the presence of a base or an acid.
Dependencies are inferred from the claim text.