Process for preparing 4-(n-hexadecylamino)-benzoic acid
AssigneeLEK, tovarna farmacevtskih in kemicnih izdelkov, n.sol.o.
InventorsBranko Jenko, Natasa Hafner-Milac, Joza Habjan, Anton Prosen, Igor Langof
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Abstract
Preparation of 4-(n-hexadecylamino)-benzoic acid or salt thereof employing as catalyst quaternary ammonium or phosphonium salt.
Claims11
In a process for the preparation of 4-(n-hexadecylamino)-benzoic acid and physiologically acceptable salts thereof by means of reacting 4-aminobenzoic acid and 1-bromohexadecane in the presence of a lower alkanol as solvent and in the presence of KOH the improvement which comprises carrying out the alkylation in the presence of a quaternary ammonium or phosphonium salt catalyst of the formula:
- [R.sub.3 Q.sup.+ Y]Cl.sup.- wherein R is ethyl, butyl or caprilyl;
- Y is methyl, benzyl or hexadecyl, and Q is nitrogen or phosphorus.
The process of claim 9 wherein the reaction is performed in 11 to 12 hours.
Dependencies are inferred from the claim text.