Method of preparing .beta.-halo esters from cyclic acetals
AssigneeVanderbilt University
InventorsDonald E. Pearson, Sidhaghatta D. Venkataramu, James H. Cleveland, Jr.
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Abstract
Beta-halo esters, such as .beta.-haloalkyl benzoates or terephthalates, are prepared by halogenative cleavage of cyclic acetals using trimethyl phosphate (TMP) or borate to mediate the reaction. The .beta.-halo esters, which are obtained in high yields, can be used to form polymers or plasticizers. Neuromuscular blocking agents such as succinylcholine and related compounds can also be prepared.
Claims12
The method of preparing .beta.-halo esters from cyclic acetals, comprising reacting under effective conditions for the reaction a cyclic acetal with halogen selected from the class consisting of bromine and chlorine in the presence of a reagent selected from the class consisting of trimethyl phosphate and trimethyl borate, in the absence of phosphorus pentoxide, said acetal containing at least one acetal group represented by:
- ##STR4## wherein R is a hydrocarbon group providing from 2 to 4 acetal ring carbons.
Dependencies are inferred from the claim text.