Process for preparing benzoxazolyl propionic acid derivatives
AssigneeRavizza S.p.A.
InventorsFrancesco Mauri, Roberto Signorini
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Abstract
The application describes a process for preparing 2-phenyl derivatives of benzoxazolyl propionic acid of formula ##STR1## in which X is H, Cl, Br, F, or a linear or branched alkyl or 1 to 6 carbon atoms. The process starts from 3-nitro-4-hydroxyphenyl-.alpha.-methyl-acetonitrile which is hydrolysed in the presence of a strong acid, the 3-nitro-4-hydroxyphenyl-.alpha.-methylacetic acid thus obtained is hydrogenated in the presence of Pd on carbon, and the 3-amino-4-hydroxyphenyl-.alpha.-methylacetic acid deriving therefrom is first reacted with benzoyl chloride or with para-substituted benzoyl chloride in the presence of an alkaline base, and then with 85% phosphoric acid to complete the formation of the oxazolinic ring.
Claims8
A process for preparing 2-phenyl derivatives of benzoxazolyl propionic acid of formula ##STR11## in which X is H, Cl, Br, F or a linear or branched alkyl of 1 to 6 carbon atoms, wherein the 3-nitro-4-hydroxyphenyl-.alpha.-methyl-acetonitrile is hydrolysed in the presence of a strong acid consisting essentially of concentrated hydrochloric acid, the 3-nitro-4-hydroxyphenyl-.alpha.-methylacetic acid thus obtained is hydrogenated in the presence of Pd on carbon, and the 3-amino-4-hydroxyphenyl-.alpha.-methylacetic acid deriving therefrom is first reacted with benzoyl chloride or with para-substituted benzoyl chloride in the presence of an alkaline base, and then with 85% phosphoric acid to complete the formation of the oxazolinic ring.
Dependencies are inferred from the claim text.