3-Aminopropoxyaryl derivatives, their preparation and pharmaceutical compositions containing them

Abstract

The compounds of formula I ##STR1## wherein R.sub.1 is hydrogen or methyl, R.sub.3 is hydrogen, methyl, hydroxymethyl, carboxyl, alkoxycarbonyl of 2 to 5 carbon atoms, carbamoyl or cyano and R.sub.2 is a group (a) to (i), groups (a) to (i) having the following significances: ##STR2## wherein n is 0 or 1 and R.sub.a, R.sub.b, R.sub.c and R.sub.d independently are hydrogen or alkyl of 1 to 4 carbon atoms; ##STR3## wherein R.sub.e is hydrogen or alkyl of 1 to 4 carbon atoms; ##STR4## wherein R.sub.h is halogen of atomic number of from 9 to 35; ##STR5## wherein R.sub.i together with R.sub.n is o-phenylene optionally substituted by alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms or halogen of atomic number of from 9 to 35 and, when R.sub.3 is cyano, R.sub.i together with R.sub.n additionally is lower alkylene separating by 2 or 3 carbon atoms the nitrogen atom to which R.sub.i is bound from the nitrogen atom to which R.sub.n is bound and R.sub.m is hydrogen or an aliphatic, cycloaliphatic, cycloaliphatic-aliphatic, araliphatic or aromatic moiety or an acyl moiety, with the provisos that, (A) when R.sub.1 is hydrogen and R.sub.2 is a group (b), R.sub.3 is methyl, hydroxymethyl, carbamoyl or cyano and (B) when R.sub.2 is a group (h), R.sub.3 is hydrogen, carbamoyl or cyano. The compounds are useful as antiarrhythmic, .alpha.-adrenergic blocking and antihypertensive agents and, when a cyano or carbamoyl group is attached in the 2-position of the indole nucleus, additionally as .beta.-adrenergic blocking agents.

Dependencies are inferred from the claim text.