Naphthyridone derivatives
AssigneeUSV Pharmaceutical Corporation
InventorsJames R. Shroff, Bernard Loev
Life of this patent
Estimating the term…
Abstract
Compounds of the formula ##STR1## wherein each of R, R.sub.1 and R.sub.2 is independently H, alkyl, alkenyl, alkoxy, halo, hydroxy, trifluoromethyl, amino, alkylamino, cyano and nitro; R.sub.3 is carbalkoxy, carboxamide alkanoyl, trifluoromethyl and cyano; and Ar is heteroaryl or ##STR2## wherein R.sub.4 and R.sub.5 have the same meaning as each of R, R.sub.1 and R.sub.2 ; and acid addition salts thereof have cardiotonic and hypertensive activity.
Claims18
A therapeutically active compound of the formula ##STR7## wherein R and R.sub.1 are independently H, alkyl, alkenyl, alkoxy, halo, hydroxy, trifluoromethyl, amino, alkylamino, cyano or nitro,
- R.sub.2 is an alkyl or alkenyl containing 1 to 5 carbon atoms,
- R.sub.3 is H, carbalkoxy, carboxamido, alkanoyl, trifluoromethyl or cyano,
- and
- Ar is heteroaryl selected from the group consisting of thiophene, furan, pyridine, thiazole, pyrimidine, pyrrole, benzofuran, quinoline, benzothiophene or a radical of the formula ##STR8## wherein R.sub.4 and R.sub.5 have the same meaning as R and R.sub.1 ;
- wherein the alkenyl groups, the alkyl groups per se and the alkyl groups in alkoxy, alkylamino, carbalkoxy and alkanoyl contain up to 10 carbon atoms;
- and acid addition salts thereof.
Dependencies are inferred from the claim text.