Benzoylphenyl lower alkanoyl piperidines
AssigneeSterling Drug Inc.
InventorBernard L. Zenitz
Life of this patent
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Abstract
1-[(3- or 4-Benzoylphenyl)-lower-alkyl]-[(CH.sub.2).sub.n -N.dbd.B]-substituted-piperidines, useful as anti-asthmatic, anti-allergic, anti-cholinergic, bronchodilator and anti-inflammatory agents, are prepared by alkylation of an appropriate substituted piperidine with a (3- or 4-benzoylphenyl)-lower-alkyl halide or tosylate; by reaction of a 1-[2-(3- or 4-lithiophenyl)-lower-alkyl]-.differential.(CH.sub.2).sub.n --N.dbd.]-substituted-piperidine with benzonitrile and hydrolysis of the resulting benzimidoyl compound; or by reduction of a 1-[.alpha.-(3- or 4-benzoylphenyl)-lower-alkanoyl]-[(CH.sub.2).sub.n --N.dbd.B]-substituted-piperidine.
Claims13
A member of the group consisting of (A) a compound having the formula ##STR7## where R is hydrogen or lower-alkyl;
- n is 0 or the integer 1;
- N.dbd.B is 1-piperidinyl, 4-morpholinyl, amino, lower-alkanoylamino, cycloalkanecarbonylamino or benzoylamino, or benzoylamino substituted in the phenyl ring by lower-alkyl, halogen or lower-alkoxy;
- the benzoyl group is attached either to the 3- or 4-position of the phenyl ring;
- and the (CH.sub.2).sub.n --N.dbd.B group is attached either to the 2-, 3- or 4-position of the piperidine ring;
- and (B) acid-addition salts thereof.
Dependencies are inferred from the claim text.