US 4,304,894 AGranted

Quaternary ammonium terpolymers

AssigneeSmith & Nephew Pharmaceuticals Ltd.

InventorsJohn K. Andrews, John G. B. Howes, Rupert A. Selway

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Abstract

Watersoluble terpolymers based on three monomer units all of formula: ##STR1## (or possibly the 5-membered ring analogue) wherein the N-substituents are respectively (A) low-low e.g. dimethyl (B) low-medium e.g. methyloctyl and (C) low-higher e.g. methyllauryl or methylcetyl, in molecular size; B:C being usually 5:1 to 0.333:1 (perferably 2:1 to 1:1) in weight ratio, and species less than 10,000 or preferably 20,000 m.w. usually being removed, have surprisingly effective sterilizing activity e.g. against Candida while (a) not accumulating in soft contact lenses, whereby they can be used as an overnight nonirritant aqueous sterilant solution at concentrations below 0.1 weight percent e.g. 0.05 or less and (b) not penetrating skin or like membrane whereby aqueous formulations can be used as topical disinfectants without systemic side-effects.

Claims14

Dependent claims

A watersoluble polymeric material wherein at least 90% by weight of the recurring monomer units consist of (A) (B) and (C) recurring units, as defined below, the 0-10% remainder by weight being units of one or more compatible monomers capable of copolymerisation, and no component (A) (B) or (C) being present in an amount less than 2% by weight:

##STR5## Wherein X is any compatible anion allowing water-solubility,
R is unsubstituted alkyl, or monohydroxyalkyl, the alkyl group in each case containing from one to four carbon atoms,
R.sub.1 is either (a) unsubstituted alkyl or monohydroxyalkyl the alkyl group in each case containing at least six carbon atoms or (b) a carbocyclic or heterocyclic mononuclear unsubstituted aryl group separated from the nitrogen atom of the piperidine ring by an unsubstituted alkylene group, containing in total up to six carbon atoms,
R.sub.2 is different from R.sub.1, and (i) where R.sub.1 is as defined at (a) is either as defined at (b) or is unsubstituted alkyl, or monohydroxyalkyl the alkyl group in this case containing at least eight carbon atoms, and always at least one more carbon atom than R.sub.1 as defined at (a) or, (ii) where R is as defined at (b), is as defined at (a).

1 more element

Dependencies are inferred from the claim text.