Process for producing 20-dihydro-20-deoxy-23-demycinosyltylosin
AssigneeEli Lilly and Company
InventorsRichard H. Baltz, Herbert A. Kirst, Gene M. Wild, Eugene T. Seno
Life of this patent
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Abstract
20-Dihydro-20-deoxy-23-demycinosyltylosin (DH-DO-DMT), 20-dihydro-20-deoxy-5-O-mycaminosyltylonolide (DH-DO-OMT), specified acyl ester derivatives, and their acid addition salts are useful intermediates and antibacterial agents. Methods of preparing DH-DO-DMT and DH-DO-OMT by fermentation of Streptomyces fradiae and the microorganism S. fradiae ATCC 31733 are included.
Claims6
The method of producing the antibiotics 20-dihydro-20-deoxy-23-demycinosyltylosin and 20-dihydro-20-deoxy-5-O-mycaminosyltylonolide which comprises cultivating Streptomyces fradiae ATCC 31733 or a mutant or recombinant thereof which produces said antibiotics in a culture medium containing assimilable sources of carbon, nitrogen, and inorganic salts under submerged aerobic fermentation conditions until a substantial amount of antibiotic activity is produced.
A biologically pure culture of Streptomyces fradiae ATCC 31733 or a mutant or recombinant thereof which produces 20-dihydro-20-deoxy-23-demycinosyltylosin or 20-dihydro-20-deoxy-5-O-mycaminosyltylonolide.
Dependencies are inferred from the claim text.