Hydroxyalkanoic acid derivatives
AssigneeImperial Chemical Industries PLC
InventorsMichael D. Edge, Wilson S. Waring
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Abstract
The invention concerns novel hydroxyalkanoic acid derivatives of the formula: ##STR1## in which A is a straight or branched chain (2-6C)alkylene, R.sup.1 and R.sup.2 are independently hydrogen or (1-6C) alkyl, and R.sup.3 is hydrogen or (1-6C)alkyl, and when R.sup.3 is hydrogen, base-addition salts thereof; and processes for their manufacture. The compounds possess useful anti-arthritic properties and the invention also concerns pharmaceutical compositions of such compounds for use in the treatment of arthritic joint diseases. A representative compound of the invention is 2-{2-[4-(4-chlorophenyl)phenyl]-ethoxy}propionic acid.
Claims7
A hydroxyalkanoic acid of the formula:
- ##STR10## wherein A is an ethylene or trimethylene diradical;
- R.sup.1 is hydrogen, a methyl, ethyl, propyl, isopropyl or butyl radical;
- and R.sup.2 is hydrogen;
- R.sup.3 is hydrogen or a (1-6C)-alkyl radical;
- or a pharmaceutically acceptable base-addition salt thereof.
2-{2-[4-(4-Chlorophenyl)phenyl]ethoxy}propionic acid, or a pharmaceutically acceptable base-addition salt thereof.
Dependencies are inferred from the claim text.