Thienyl, thienyloxy or furyl substituted prostaglandin derivatives in the 6-keto-PGE.sub.1 series
AssigneeHoechst Aktiengesellschaft
InventorsGerhard Beck, Ulrich Lerch, Bernward Scholkens, Richard H. Rupp
Life of this patent
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Abstract
The invention relates to new prostaglandin derivatives of the 6-keto-PGE.sub.1 series, to processes and intermediates for their manufacture and to their use as medicaments.
Claims5
A compound of the formula ##STR56## wherein R.sup.1 is hydrogen, linear or branched alkyl having up to 8 carbon atoms, linear or branched unsaturated aliphatic hydrocarbon having 3 to 6 carbon atoms, cycloaliphatic hydrocarbon having 3 to 7 carbon atoms, araliphatic hydrocarbon having 7 to 9 carbon atoms, a physiologically acceptable metal ion, NH.sub.4.sup.+ ion, an ammonium ion derived from a primary, secondary or tertiary amine or a tetraalkylammonium ion;
- R.sup.2 is linear or branched alkyl having up to 8 carbon atoms and substituted with .alpha.- or .beta.-thienyl, .alpha.- or .beta.-thienyloxy, .alpha.- or .beta.-furyl, or such thienyl, thienyloxy, or furyl mono-, di-, or tri-substituted in the nucleus with halogen, trifluoromethyl, or alkyl or alkoxy each having 1 to 6 carbon atoms;
- and
- R.sup.3 is hydrogen or an easily-detachable protective group.
Dependencies are inferred from the claim text.