Psychotropic deuterated derivatives of phenylhydantoin and pharmaceutical compositions comprising such derivatives
AssigneeRegion Wallonne
InventorsPierre A. Dumont, Jacques H. Poupaert
Life of this patent
Estimating the term…
Loading patent…
AssigneeRegion Wallonne
InventorsPierre A. Dumont, Jacques H. Poupaert
Estimating the term…
Psychotropic composition comprising as an active constituent, a pharmaceutical composition, more particularly a psychotropic composition, characterized in that it comprises as an active constituent, a deuterated phenylhydantoin corresponding to the general formula ##STR1## wherein radicals R.sub.1 are identical or different and represent hydrogen or methyl, R.sub.2 is ethyl or a substituted or unsubstituted phenyl group, which is deuterated or not, R.sub.3 is hydrogen, halogen or a linear or ramified alkyl radical comprising 1 to 4 carbon atoms, a linear or ramified alkoxy radical comprising 1 to 4 carbon atoms, a trifluoromethyl, hydroxy, nitro or amino radical, X is an oxo, thio or methylene group and x is an integer of 1-5, one of its enantioners or one of its salts with a physiologically acceptable base, in combination with a pharmaceutically acceptable vehicle.
A psychotropic pharmaceutical composition, which comprises as an active constituent, a therapeutically effective amount of a deuterated phenylhydantoin corresponding to the formula ##STR5## wherein R.sub.1, which may be the same or different, represents hydrogen or methyl, R.sub.2 is ethyl, unsubstituted phenyl or phenyl substituted by halogen, straight chain or branched chain alkyl comprising 1 to 4 carbon atoms, straight or branched chain alkoxy comprising 1 to 4 carbon atoms, trifluoromethyl, nitro or amino, which phenyl or substituted phenyl may be deuterated, R.sub.3 is hydrogen, halogen, straight chain or branched chain alkyl comprising 1 to 4 carbon atoms, straight or branched chain alkoxy comprising 1 to 4 carbon atoms, trifluoromethyl, nitro or amino, X is oxo, thio or methylene and x is an integer, with the proviso that the deuteration in R.sub.2 and due to d.sub.x is such that said deuterated phenylhydantoin corresponding to the formula (I) is a mono- or penta-deuterated phenylhydantoin, one of its enantiomers or one of its salts with a physiologically acceptable base, in combination with a pharmaceutically acceptable vehicle.
Dependencies are inferred from the claim text.