Treatment of ulcers and hypertension
AssigneeJohn Wyeth & Brother Limited
InventorRoger Crossley
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Abstract
The invention concerns the treatment of ulcers and hypersecretion in a mammal using compounds of the formula I Ar--A--S--Y I where Ar is phenyl, which may be substituted or cycloalkyl of 5 to 7 carbon atoms, A is saturated or unsaturated lower alkylene which may be substituted by lower alkyl, oxo or hydroxy, S is sulphur and Y is an optionally substituted pyridine, pyridinium, tetrahydropyridine or tetrahydropyridinium radical. Certain novel compounds and pharmaceutical compositions are also disclosed.
Claims11
A method for treating ulcers or hypersecretion in a mammal which comprises administering to said mammal an effective amount of a compound of formula I
- Ar--A--S--Y I
- wherein Ar represents a cycloalkyl group of 5 to 7 carbon atoms, or a phenyl group which may be substituted by one or more of the following:
- halogen, nitro, lower alkoxy, hydroxy, hydroxyloweralkyl, loweralkoxyloweralkyl, amino, loweralkylamino, aralkoxy, diloweralkylamino, loweralkyl, aryl or aralkyl of 7 to 10 carbon atoms or disubstituted by a loweralkylenedioxy radical;
- A represents a saturated or olefinically unsaturated alkylene radical having from 1 to 6 carbon atoms, which may be substituted by lower alkyl of 1 to 6 carbon atoms, oxo, or hydroxy, S is sulphur and Y is a radical of formula ##STR3## wherein R.sup.1 is hydrogen, lower alkyl, hydroxylower alkyl, loweralkoxyloweralkyl, loweralkoxy, halogen, formyl, phenyl, phenylalkyl or acetal i.e. CH(OR.sup.4).sub.2 where R.sup.4 is lower alkyl or two R.sup.4 radicals are joined to form a lower alkylene chain, R is lower alkyl of 1-4 carbon atoms, aryl or aralkyl of 7 to 12 carbon atoms, m is 1 or 2 and Z.sup.- is an anion, or an acid addition salt of a compound containing a radical of formula II or IIa, with the proviso that when Y is a radical of formula II, Ar is other than aralkoxyphenyl.
Dependencies are inferred from the claim text.