Aminoalkylthiophene derivatives as histamine H.sub.2 -antagonists

A compound of the formula (II) ##STR40## or a physiologically acceptable salt, N-oxide or hydrate thereof, in which Y represents .dbd.O, .dbd.S, .dbd.CHNO.sub.2 or .dbd.NR.sub.3 where R.sub.3 represents hydrogen, nitro, cyano, lower alkyl, phenyl or phenyl substituted with one or more lower alkyl, lower alkoxy or halogen groups;

• lower alkylsulphonyl or phenylsulphonyl, substituted phenylsulphonyl wherein said substituents are one or more lower alkyl, lower alkoxy or halogen groups;
• R.sub.1, R.sub.2, R.sub.5 and R.sub.6, which may be the same or different, each represents hydrogen, lower alkyl, C.sub.3-7 cycloalkyl, lower alkenyl, or C.sub.1-3 alkyl wherein the aryl portion is phenyl or phenyl substituted with one or more lower alkyl, lower alkoxy or halogen groups;
• lower alkyl interrupted by an oxygen atom or lower alkyl interrupted by a group ##STR41## where R.sub.4 represents hydrogen or lower alkyl or R.sub.1 and R.sub.2 together with the nitrogen atom to which they are attached or R.sub.5 and R.sub.6 together with the nitrogen atom to which they are attached form a pyrrolidone or piperidine ring;
• Q represents a thiophen ring in which incorporation into the rest of the molecule is through bonds at the 2- and 5-positions;
• Q' represents a thiophen ring in which incorporation into the rest of the molecule is through bonds at the 2- and 5-positions, or a benzene ring in which incorporation into the rest of the molecule is through bonds at the 1- and 3-positions;
• X and E, which may be the same or different, each represents --CH.sub.2 --, --O-- or --S--;
• n and p, which may be the same or different, each represents zero, 1 or 2;
• m and q, which may be the same or different, each represents 2, 3 or 4;
• Alk and Alk', which may be the same or different, each represents a straight chain alkylene group of 1 to 3 carbon atoms;
• except that n is not zero when X is oxygen and p is not zero when E is oxygen and Q' is a thiophen ring system.

A compound of the formula (III) ##STR42## or a physiologically acceptable salt, N-oxide or hydrate thereof, in which Y represents .dbd.O, .dbd.S, .dbd.CHNO.sub.2 or .dbd.NR.sub.3 where R.sub.3 represents hydrogen, nitro, cyano, lower alkyl, phenyl, phenyl substituted with one or more lower alkyl, lower alkoxy or halogen groups;

• lower alkylsulphonyl or phenylsulphonyl, substituted phenylsulphonyl wherein said substituents are one or more lower alkyl, lower alkoxy, or halogen groups;
• R.sub.1 and R.sub.2, which may be the same or different, each represents hydrogen, lower alkyl, C.sub.3-7 cycloalkyl, lower alkenyl, or C.sub.1-3 alkyl wherein the aryl portion is phenyl or phenyl substituted with one or more lower alkyl, lower alkoxy or halogen groups;
• lower alkyl interrupted by an oxygen atom, lower alkyl interrupted by ##STR43## in which R.sub.4 represents hydrogen or lower alkyl;
• or R.sub.1 and R.sub.2 together with the nitrogen atom to which they are attached from a pyrrolidine or piperidine ring;
• Q represents a thiophen ring in which incorporation into the rest of the molecule is through bonds at the 2- and 5-positions;
• X represents --CH.sub.2 --, --O-- or --S--;
• n represents zero or 1 except that n is not zero when X is oxygen;
• m represents 2, 3 or 4;
• Alk represents a straight chain alkylene group of 1 to 3 carbon atoms;
• q represents 2, 3 or 4 or can additionally represent zero or 1 when E is a --CH.sub.2 -- group;
• p represents zero, 1 or 2;
• E represents --CH.sub.2 --, --O--, or --S--;
• and
• Z' represents a phenyl ring optionally substituted by at least one of lower alkyl, hydroxy lower alkyl, hydroxy, amino, lower alkoxy or halo or a furyl, pyridyl or imidazolyl ring attached via a carbon atom and optionally substituted by lower alkyl optionally substituted by hydroxy or halo;
• except that p is not zero when E is oxygen and Z' is furyl.