6-(Pyridinyl)-3(2H)-pyridazinones and their use as cardiotonics
AssigneeSterling Drug Inc.
InventorsGeorge Y. Lesher, William B. Dickinson
Life of this patent
Estimating the term…
Abstract
2-R-6-PY-3(2H)-pyridazinones (I) or salts thereof, which are useful as cardiotonics, where R is hydrogen, lower-alkyl or lower-hydroxyalkyl, and PY is 4- or 3-pyridinyl or 4- or 3-pyridinyl having one or two lower-alkyl substituents, are prepared by reacting 2-R-4,5-dihydro-6-PY-3(2H)-pyridazinone with a dehydrogenating agent. Also shown are: cardiotonic compositions and a method for increasing cardiac contractility using I or salts; and, the preparation of the corresponding intermediate 4,5-dihydro compounds.
Claims16
A 2-R-6-PY-3(2H)-pyridazinone having the formula ##STR3## or pharmaceutically-acceptable acid-addition salt thereof, where PY is 4-pyridinyl or 4-pyridinyl having one or two lower-alkyl substituents, and R is hydrogen, lower-alkyl or lower-hydroxyalkyl.
6-(4-Pyridinyl)-3(2H)-pyridazinone or pharmaceutically-acceptable acid-addition salt thereof.
2-Methyl-6-(4-pyridinyl)-3(2H)-pyridazinone or pharmaceutically-acceptable acid-addition salt thereof.
A cardiotonic composition for increasing cardiac contractility, said composition comprising a pharmaceutically-acceptable inert carrier and, as the active component thereof, an effective amount of a cardiotonic 2-R-6-PY-3-(2H)-pyridazinone or pharmaceutically-acceptable acid-addition salt thereof where R is hydrogen, lower-alkyl or lower-hydroxyalkyl, and PY is 4-pyridinyl or 4-pyridinyl having one or two lower-alkyl substituents.
The method for increasing cardiac contractility in a patient requiring such treatment which comprises administering orally or parenterally in a solid or liquid dosage form to such patient an effective amount of a cardiotonic 2-R-6-PY-3(2H)-pyridazinone or pharmaceutically-acceptable acid-addition salt thereof, where R is hydrogen, lower-alkyl or lower-hydroxyalkyl, and PY is 4-pyridinyl or 4-pyridinyl having one or two lower-alkyl substituents.
Dependencies are inferred from the claim text.