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US 4,304,775 AGranted
3-Hydrazino-6-(pyridinyl) pyridazines and cardiotonic use thereof
AssigneeSterling Drug Inc.
InventorsGeorge Y. Lesher, William B. Dickinson
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AssigneeSterling Drug Inc.
InventorsGeorge Y. Lesher, William B. Dickinson
Estimating the term…
3-Hydrazino-6-PY-pyridazine or pharmaceutically-acceptable acid-addition salt thereof is useful as a cardiotonic agent, where PY is 4- or 3-pyridinyl or 4- or 3-pyridinyl having one or two lower-alkyl substitutents. 6-PY-3-pyridazinol is prepared by reacting 6-PY-3-pyridazinol with a chlorinating agent to produce 3-chloro-6-PY-pyridazine and reacting said 3-chloro compound with hydrazine to produce said 3-hydrazino compound. 3-Hydrazino-6-PY-pyridazine or pharmaceutically-acceptable acid-addition salt thereof is disclosed as the active component in cardiotonic compositions for increasing cardiac contractility and in the method for increasing cardiac contractility in a patient requiring such treatment. The novel intermediate 3-chloro-6-PY-pyridazine is prepared as noted above.
3-Hydrazino-6-PY-pyridazine or pharmaceutically-acceptable acid-addition salt thereof, where PY is 4- or 3-pyridinyl or 4- or 3-pyridinyl having one or two lower-alkyl substituents.
3-Hydrazino-6-(4-pyridinyl)pyridazine or pharmaceutically-acceptable acid-addition salt thereof.
A cardiotonic composition for increasing cardiac contractility in a patient requiring such treatment, said composition consisting essentially of a pharmaceutically-acceptable inert carrier and, as the active component thereof, an effective amount of the cardiotonic 3-hydrazino-6-PY-pyridazine or pharmaceutically-acceptable acid-addition salt thereof, where PY is 4-or 3-pyridinyl or 4- or 3-pyridinyl having one or two lower-alkyl substituents.
The method for increasing cardiac contractility in a patient requiring such treatment which comprises administering orally or parenterally in a solid or liquid dosage form to such patient a composition consisting essentially of a pharmaceutically-acceptable inert carrier and, as the active component thereof, an effective amount of the cardiotonic 3-hydrazino-6-PY-pyridazine or pharmaceutically-acceptable acid-addition salt thereof, where PY is 4- or 3-pyridinyl or 4- or 3-pyridinyl having one or two lower-alkyl substituents.
Dependencies are inferred from the claim text.