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US 4,304,766 AGranted
Compositions for reducing elution of therapeutic agents from teeth
AssigneeMinnesota Mining and Manufacturing Company
InventorRobert W. H. Chang
Life of this patent
Estimating the term…
Abstract
A dentifrice composition containing a water-dispersible, membrane-forming material which, when applied to tooth surfaces in an oral environment, attaches thereto and forms a substantially continuous, hydrophobic barrier thereon which substantially reduces elution of a previously applied therapeutic agent.
Claims12
A dentifrice composition for substantially effectively coating previously fluoride-treated teeth and thereby reducing elution of said fluoride from said teeth, said composition comprising
- a fluoride-containing caries prophylactic agent provided that said agent is substantially free from polyvalent metal atoms;
- and
- at least about 0.05% by weight of an anionic water-dispersible, membrane-forming material which, when applied to the surface of said previously fluoride-treated teeth in an oral environment, complexes with the calcium of said teeth and forms a substantially continuous hydrophobic barrier thereon which substantially reduces the elution of said previously applied fluoride:
- alkali metal, ammonium and amine groups, and alkyl, aryl, cycloalkyl, alkaryl, and aralkyl groups each containing up to 20 carbon atoms;
- M is selected from hydrogen, alkali metal, ammonium and amine groups;
- m is 1 or 2;
- g is an integer of from 1 to 10;
- k is 1 or 2;
- and q is 3-k;
- and
- R.sup.6 CON(R.sup.2)R.sup.3 COOM
- wherein R.sup.2, R.sup.3, and M are as defined above;
- R.sup.5 is a hydrocarbon group containing from 6 to 24 carbon atoms;
- and R.sup.6 is a hydrocarbon group containing from 10 to 20 carbon atoms.
11 more elements
Dependencies are inferred from the claim text.