9.alpha.-Debromination
AssigneeThe Upjohn Company
InventorsJames B. Heather, David R. White
Life of this patent
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Abstract
A process for 9.alpha.-debromination of 9.alpha.-bromo-11.beta.-hydroxy steroids without eliminating the 11.beta.-hydroxyl group utilizing chromous chloride or chromous sulfate and thioglycolic acid.
Claims16
A process for the preparation of an 11.beta.-hydroxy pregnane of the formula
- which comprises reacting a 9.alpha.-halo-11.beta.-hydroxy pregnane of the formula ##STR2## with chromous sulfate or chromous chloride or mixtures thereof and HS--CH.sub.2 --COOH, where R.sub.6, R.sub.9, R.sub.16, R.sub.17, R.sub.21, and .about. are defined in the specification.
A process for the preparation of an 11.beta.-hydroxy androstane of the formula ##STR3## which comprises reacting a 9.alpha.-halo-11.beta.-hydroxy androstane of the formula ##STR4## with chromous sulfate or chromous chloride or mixtures thereof and HS--CH.sub.2 --COOH, where R.sub.6, R.sub.9, R.sub.16, and .about. are defined in the specification.
Dependencies are inferred from the claim text.