2-Azetidinone compounds and processes for preparation thereof
AssigneeFujisawa Pharmaceutical Co., Ltd.
InventorsTakashi Kamiya, Masashi Hashimoto, Osamu Nakaguti, Teruo Oku, Yoshiharu Nakai, Hidekazu Takeno
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Abstract
This invention relates to new 2-azetidinone compounds, which have antimicrobial activities, and to processes for the preparation thereof, and more particularly, this invention provides new 2-azetidinone compounds, especially ones having various substituted carboxyalkyl radicals at the first position and having various groups at the fourth position of the azetidinone nucleus, which have antimicrobial activities against various pathogenic microorganisms and are useful as antibiotics in treatment for microbial infections in mammal including human being and animals.
Claims4
A compound of the formula:
- ##STR83## wherein R.sup.1 is amino, azido, phthalimido or acylamino of the formula:
- ##STR84## in which R.sup.a is hydrogen or lower alkoxy which may be substituted by one to three substituents selected from amino, carboxy, lower alkoxycarbonylamino, lower alkoxycarbonyl and lower alkoxyphenyl(lower)alkoxycarbonyl,
- R.sup.b is hydrogen, amino, phenyl(lower)alkoxycarbonylamino or halo(lower)alkoxycarbonylamino and
- R.sup.c is hydrogen, or
- R.sup.b and R.sup.c are linked together to form oxo or hydroxyimino, and
- R.sup.d is phenoxy(lower)alkyl, thienyl(lower)alkyl, or phenyl substituted by one substitutent selected from N-lower alkylcarbamoyl and carboxy, and
- R.sup.3 is a group of the formula:
- ##STR85## in which R.sup.4 is 5-membered heterocyclic group, the ring atoms of which are 4 carbon atoms and one sulfur or one oxygen atom,
- R.sup.5 is carboxy or lower alkoxycarbonyl,
- R.sup.6 is lower alkyl, alkylthiadiazolylthio(lower)alkyl or benzothiazolylthio(lower)alkyl, and
- R.sup.7 is alkylthiadiazolylthio(lower)alkyl or benzothiazolylthio(lower)alkyl.
Dependencies are inferred from the claim text.