16-Phenoxy prostaglandin F.sub.2.alpha. analogs
AssigneeThe Upjohn Company
InventorNorman A. Nelson
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Abstract
Prostaglandin-type compounds with a phenoxy or substituted-phenoxy substituent at the C-16 position are disclosed, with processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, labor inducement at term, and wound healing.
Claims31
An optically active compound of the formula ##STR53## or a racemic compound of that formula and the mirror image thereof, wherein g is an integer from 2 to 5, inclusive;
- wherein M is ##STR54## wherein R.sub.1 is hydrogen or alkyl of one to 12 carbon atoms, inclusive, cycloalkyl of 3 to 10 carbon atoms, inclusive, aralkyl of 7 to 12 carbon atoms, inclusive, phenyl, or phenyl substituted with one, 2, or 3 chloro or alkyl of one to 4 carbon atoms, inclusive;
- wherein R.sub.2 and R.sub.3 are hydrogen, methyl, or ethyl;
- wherein T is alkyl of one to 3 carbon atoms, inclusive, fluoro, chloro, trifluoromethyl, or --OR.sub.4 wherein R.sub.4 is alkyl of one to 3 carbon atoms, inclusive, and wherein s is zero, one, 2, or 3, with the proviso that not more then two T's are other than alkyl;
- including each of the lower trialkanoates thereof, and each of the pharmacologically acceptable salts thereof when R.sub.1 is hydrogen.
16-(.alpha.,.alpha .,.alpha.-Trifluoro-p-tolyloxy)-19,20-dinor-PGF.sub.2.alpha., a compound according to claim 10.
Dependencies are inferred from the claim text.